This is Dr. Wily as he appeared in the original Mega Man.  Professional, calm, and prepared (check out that pen in his pocket), this is a man of science and rationality.  Truly he's one of the most gifted roboticists of his time.

After suffering defeat, the doctor returns for Mega Man 2 with a little arrogance.  Note the condescending finger-wag, the smirk on his face, and his first use of his iconic evil eyebrows meant to taunt the viewer.

Dr. Wily feigned reform in Mega Man 3, but his true colors were revealed after he stole the peacekeeping robot he built with Dr. Light.  His eyebrows are still in full force and he's stopped buttoning his lab coat, showing us a more informal demeanor.

That informal demeanor looks a little more threatening with his fists balled up for Mega Man 4.  Maybe we should have scheduled an intervention by now.

By the time of Mega Man 5, Dr. Wily has turned his anger on the viewer with a taunting wag of his finger.  He's letting his hair grow long and has stopped trying to brush it into place.  Obviously his obsession has consumed him.  It's hard to help someone when they lash out at you.

Oh no, who let him have tools?  For Mega Man 6, his confident open-mouthed grin has devolved into a teeth-clenched grimace.  I think even he's starting to realize this isn't funny anymore.  The curl of his necktie implies motion as if he's just taken a swing at the viewer with his screwdriver.  His lab coat is taking on the qualities of a cape by now.  There might be a wind machine just out of frame.

There's definitely a wind machine.  This is not the pose of a man who has control of his faculties.  Being jailed prior to Mega Man 7 has truly cracked him.  Maybe, if we all band together, we can still-

OH FOR CRYING OUT LOUD, HE'S WEARING A GODDAMNED SKULL ON HIS BELT!

That's it.  I'm done.  I'm afraid that Dr. Wily is beyond our ability to help him.  You can't save someone who just doesn't want to be saved.

(Images via Mega Man Knowledge Base, The Mega Man Network, and Capcom Database)