Do you know the secret to creating a solid video game parody video? Proper use of authentic sound effects. Consider these two clips, the first from Dueling Analogs that explores rejected characters for Super Mario Bros. Crossover such as Pac-Man and Lizzie from Rampage and the second from College Humor that features alleged Super Easy Mode in popular titles such as Sonic the Hedgehog, Space Invaders, and The Legend of Zelda. While the sprite animation is clever enough, it's the use of sound effects in key places that sparked the most laughter from me. Hopefully you'll agree.
(Dueling Analogs video via Gaming Succubus)