Following up on the talk that actress Sigourney Weaver declined to reprise the role of Dana Barrett in the upcoming Ghostbusters: The Video Game comes confirmation that Alyssa Milano will take over as the new female lead in the story, joining the Ghostbusters world as part of the World Of Gozer exhibit that figures into the plot.  Variety explains.

"Obviously, fans of the movie are going to miss Sigourney Weaver," said Milano, who was offered the part of the game's leading lady after Weaver declined to reprise her role as Dana Barrett. "I have so much respect for that character in the movie that I hope I do the position that she is in justice. I was just flattered to be asked to be part of 'Ghostbusters'."

In the game, players become a Ghostbusters recruit who assists the original team to take down ghastly foes like the ginormous Stay Puft Marshmallow Man and god of destruction Gozer. Milano said she spent one day in the studio voicing the character of Dr. Ilyssa Selwyn, the brainy guest curator of a "World of Gozer" exhibit at the Natural History Museum.  "It's a little tricky because you have no idea what it will look like," said Milano.

Ilyssa Selwyn?  That's an unusual name.  Lots of Ls and Ys in there.  And is it mere coincidence that "Ilyssa Selwyn" is an anagram for "We lay sly sins"?  I think not!  Fine, maybe I am reaching for something that isn't there.  Take a look at the other 496 anagrams formed from her name and see if you can find anything better.  Once you finish with that you should head on over to PlayStation Only to see some video of the game's multiplayer mode in action plus what may be the first in-game look at the psychoreactive pink mood slime from the second film.

(Alyssa Milano news via Joystiq, video clip via Terminal Reality's Glenn Gamble)